Self-report and concordance in urinary drug detection in women with co-occurring PTSD and substance use disorders participating in a clinical trial: influence of drug type and participant characteristics (2023)

Table of Contents
drug and alcohol addiction Abstract below methods Results conclusions excerpts section Current study participants and process Objective 1: Examine the relationship between UDS and self-reported substance use discussion role of the funding source Contribution statement written by CRediT Conflict of Interest Statement Gracias references(39) Concordance between self-report and urine drug detection data in adolescent participants in opioid-dependent clinical trials Addicted. Behave Racial differences in the validity of self-reported drug use among men who have sex with men in Atlanta, GA drugs alcohol depends on it. Reliability of students' self-reported consumption behavior J. Support A bus. Superallo. Hair analysis and its agreement with the self-report of drug users who attend the emergency department drugs alcohol depends on it. Down the Drain: Rethinking Routine Urine Drug Screening During the COVID-19 Pandemic J. Support A bus. Superallo. A comparison of the usefulness of urine and hair tests in detecting self-reported drug use in young adult opioid users. drugs alcohol depends on it. Comparison of self-report and oral fluid tests to detect substance use in adult patients in primary care drugs alcohol depends on it. Concordance between self-reported substance use and toxicology in HIV-infected and uninfected adolescents at risk drugs alcohol depends on it. Clinical interpretation of urine drug tests: what clinicians need to know about urine drug tests Clínica Maio proc. Urine Drug Screening: A Practical Guide for Clinicians Gender and gender differences in substance use disorders Klin. psychoanalyze. Rev. Drug use, self-report and urinalysis drugs alcohol depends on it. Refusal to use opioids confirmed by urinalysis in prescription opioid dependence J. Support A bus. Superallo. Objective test: urine and other drug tests growing child North Psychiatrist Clinic am. The impact of inconsistent self-reports of substance use in clinical trial research Addicted. Behave First Evidence for the Reliability and Meaning of a "Lite" Version of the Addiction Severity Index drugs alcohol depends on it. Opioid and cocaine use in primary care patients with self-report buprenorphine and urine drug test drugs alcohol depends on it. Testing for illicit drug use in mental health services Adult psychiatrist. get over it Validity of self-reported drug use by university students: concordance between self-reported use and urinary use psychotheme Cited by (0) Featured Articles (5) Changes in positive and negative affect after prolonged exposure to alcohol-associated posttraumatic stress disorder: secondary analysis of a randomized clinical trial Patterns of multiple substance use and clinical comorbidity in individuals seeking treatment for substance use: an observational study. Opioid and cannabis use: the role of opioid use in managing negative effect Individual and school patterns of substance use and mental health symptoms in a population sample of high school students: a multilevel latent profile analysis. The association between recreational cannabis use and post-traumatic stress disorder: a systematic review and methodological critique of the literature FAQs Videos

drug and alcohol addiction

Banda 244,

March 1, 2023

, 109769

Author links open overlay panel, , , , , , , , , , ,

Abstract

below

Self-report measures are important in assessing substance use, but they can report errors. urinemedicineScreens (UDS) are often seen as a more valid alternative. However, self-recording of UDS may not always be possible, which helps to understand factors that affect the validity of self-reported substance use.

methods

In this secondary analysis of data from 295 women with concurrent illnessesexpectedand substance use disorders (SUD) participating in a clinical trial testing behavioral interventions, we examined agreement and disagreement between self-reported drug use and associated UDS scores. Generalized linear mixed models were used to examine the effects of treatment type and participant characteristics on associations between self-reported drug use and UDS outcomes.

Results

The results revealed a greater discrepancy between the self-report and the UDS foropioidsmitranquilizers(range 0.77 to 0.90) and lower rejection rates for cannabis and cocaine (range 0.26 to 0.33). The type of treatment was not a significant moderator of the associations between self-report and UDS for all medications. Among those with a positive opioid UDS, those who reported employment in the past three years were more likely not to report opioid use than their peers without employment in the past three years.

conclusions

The findings add to the literature supporting the validity of self-reported marijuana and cocaine use. The larger discrepancies between self-report and UDS test results for opioids and sedatives suggest that an additional UDS may be required, although a variety of factors other than inaccurate self-report may be associated with this discrepancy.

(Video) Evaluating Inclusion and Exclusion Criteria in Clinical Trials

excerpts section

Current study

Overall, the results suggest that discrepancies between self-reported substance use and UDS may vary by drug type, individual characteristics, and contextual stresses and influences in particular individuals. Although previous studies have provided important information about the role of these factors in influencing concordance rates between self-report and UDS, few studies have examined this issue in people with SUD and co-occurring post-traumatic stress disorder (PTSD) and among people.

participants and process

Data for this secondary analysis come from the Women and Trauma study conducted as part of the National Clinical Trials Network for the Treatment of Drug Abuse (CTN-0015). Detailed information on the study protocol and primary endpoints has been published elsewhere (Hien et al., 2009). In summary, the Women and Trauma study examined the efficacy of two manual treatments: 1) Seeking Safety (SS), a treatment for co-occurring PTSD and SUD, compared to 2) Women's Health Education (WHE), a

Objective 1: Examine the relationship between UDS and self-reported substance use

When discrepancy was assessed, sensitivity (ie, the proportion of participants reporting no drug use [ie, unreported substance use] among those with a positive UDS) was highest for sedatives (0.90) , followed by opioids (0.77) and much more. lower for marijuana (0.33) and cocaine/stimulants (0.26). Specificity (ie, the proportion of participants reporting drug use among UDS-negative participants) was low and constant for all drugs, with a range of 0.02 to 0.03 for all drugs.

discussion

This secondary analysis examined the concordance between self-reported drug use and UDS scores in a sample of women with PTSD + UDS who participated in a randomized treatment clinical trial. Moderation effects were also examined to determine whether treatment assignment and key demographic variables (race, age, occupation, and criminal history) affected associations between self-report and UDS.

The results showed a greater discrepancy between self-reports and UDS for opioids and tranquilizers.

role of the funding source

The work presented in this manuscript was supported by grants from the National Institute on Drug Abuse (NIDA;U10 DA13035(Edward Nunes, IP),U10 DA13714(Dennis Donovan, IP),U10 DA13038(Kathleen Carroll, IP),U10 DA13732(Eugenio Somoza, PI),U10 DA13727(Kathleen Brady, IP),U10 DA013720(José Szapocznik, IP),U10 DA013046(John Rotrosen),R25DA035161(Lesia M. Ruglass and Denise A. Hien, MPI) and the National Institute on Alcohol Abuse and Alcoholism (NIAAA;R01AA025853, Denise A. El

Contribution statement written by CRediT

LM Ruglass, T. K. Killeen, and AA Morgan-López conceived and designed the research question. Y. Zhao and A. Shevorykin performed the statistical analyses. All authors wrote the original manuscript, interpreted the results, and critically reviewed and revised the manuscript. All authors approved the final manuscript as submitted.

Conflict of Interest Statement

none.

Gracias

We thank the reviewers of the NIDA Substance Abuse Treatment Clinical Trials Network National Publication Committee for their review and comments on this manuscript.

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      Many people with post-traumatic stress disorder (PTSD) report increased negative affect (NA) and decreased positive affect (PA). Little is known about whether PTSD treatments improve blood pressure. We performed a secondary analysis of a randomized clinical trial comparing integrated exposure therapy (I-PE) with integrated coping therapy (I-CS) for comorbid PTSD and alcohol use disorder (AUD). veterans (norte= 119) were randomized to 12–16 weeks I-LE (norte=63) o I-CS (norte=56) and complete BP and AN measurements at baseline, after treatment, and at 3 and 6 month follow-up. The analysis sample included 80 (67%) participants with the required data. A significantly higher proportion of the total sample achieved "clinical" values ​​(i.e., ±0.5Dakota del Surfar from the general population average) for NA than for PA at baseline but not at follow-up. After treatment, the I-PE group showed a significantly greater change in NA than in PA. The change in NA compared to PA was not significantly different in the I-CS group. In the complete sample, the reduction in AN was significantly greater than the increase in BP after treatment; a change in NA but not PA was independently associated with changes in symptoms. The results provide a first assessment of the effectiveness of treatment in simultaneously repairing PA and NA and suggest room for improvement in both PTSD and AUD individuals.

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      After controlling for pain severity and relevant demographics, the cause remained associated with more anxiety, depression, and opioid-related problems (but not with increased opioid use). Furthermore, through the serial effect of negative affect (anxiety, depression) and coping motives, Couso was indirectly linked to opioid-related problems. Tests of alternative models found that co-use was not indirectly associated with anxiety or depression through the serial effects of opioid problems and coping.

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    © 2023 Elsevier B.V. All rights reserved.

    FAQs

    What is the relationship between PTSD and substance abuse? ›

    Substance Abuse and Co-occurring PTSD

    Attempting to self-medicate can be a cause to why many people with PTSD also abuse substance. The thought is that by abusing substances, a person with PTSD, will null or avoid PTSD symptoms. Those with PTSD with a SUD are more likely so abuse alcohol over drugs, such as cocaine.

    Is PTSD a comorbid substance use disorder? ›

    PTSD and SUD often co-occur. According to one national epidemiologic study, 46.4% of individuals with lifetime PTSD also met criteria for SUD (1). In another national epidemiologic study, 27.9% of women and 51.9% of men with lifetime PTSD also had SUD (2).

    What does the combination of substance use disorder and posttraumatic stress disorder contribute to? ›

    Individuals with co-occurring SUD and PTSD incur heightened risk for other psychiatric problems (e.g., depression, anxiety), suicidality, neuropsychological impairment, increased morbidity and mortality, unemployment, and social impairment [2, 5, 7, 8].

    What does an abnormal drug test mean? ›

    What Abnormal Results Mean. Elevated levels of alcohol or prescription drugs can be a sign of intentional or accidental intoxication or overdose. The presence of illegal drugs or drugs not prescribed for the person indicates illicit drug use .

    What are co occurring disorders with PTSD? ›

    Major depression and substance use disorder are particularly common in people with PTSD. They may also have an increased risk of panic disorder, agoraphobia, obsessive-compulsive disorder (OCD), dissociative disorders, and social phobia.

    What kind of trauma leads to addiction? ›

    Many associate childhood trauma with child abuse, but other stress-inducing and traumatic experiences linked to an elevated vulnerability to addiction include neglect, the loss of a parent, witnessing domestic or other physical violence, and having a family member who suffers from a mental illness.

    What is the most common comorbid disorder with PTSD? ›

    Approximately 80 percent of patients with PTSD have at least one comorbid psychiatric disorder. The most common comorbid disorders include depression, alcohol and drug abuse, and other anxiety disorders.

    What are the 4 categories of substance use disorder? ›

    Patients are diagnosed with a specific type of disorder based on the primary substance that they misuse, such as an alcohol use disorder, or opioid use disorder, stimulant use disorder, marijuana use disorder or sedative use disorder.

    What are 3 substance use disorders? ›

    Types of Substance Use Disorders
    • Alcohol use disorder.
    • Cannabis use disorder, also known as marijuana use disorder.
    • Phencyclidine use disorder, a type of hallucinogen.
    • Other hallucinogen-use disorder, which includes hallucinogens other than phencyclidine.
    • Inhalant use disorder.
    • Opioid use disorder.
    Sep 14, 2022

    What are the 5 factors influencing substance use and abuse? ›

    Risk Factors for High-Risk Substance Use
    • Family history of substance use.
    • Favorable parental attitudes towards the behavior.
    • Poor parental monitoring.
    • Parental substance use.
    • Family rejection of sexual orientation or gender identity.
    • Association with delinquent or substance using peers.
    • Lack of school connectedness.

    What is the connection between trauma and addiction to drugs? ›

    Correlation Between Addiction and Trauma

    Trauma increases the risk of developing substance abuse, and substance abuse increases the likelihood of being re-traumatized by engaging in high-risk behavior. It is also true that individuals who are abusing drugs or alcohol are less able to cope with traumatic events.

    What are 2 risk factors for substance use disorders? ›

    Risk factors
    • Family history of addiction. Drug addiction is more common in some families and likely involves an increased risk based on genes. ...
    • Mental health disorder. ...
    • Peer pressure. ...
    • Lack of family involvement. ...
    • Early use. ...
    • Taking a highly addictive drug.
    Oct 4, 2022

    What can cause a false positive on a urine drug screen? ›

    Clinically, a false positive urine drug screen can be due to numerous xenobiotics: dextromethorphan, diphenhydramine, doxylamine, ibuprofen, imipramine, ketamine, meperidine, venlafaxine, buproprion, methylenedioxpyrolvalerone (MDPV), and tramadol.

    What can make a urine drug test invalid? ›

    Invalid Sample

    “The result of a drug test for a urine specimen that contains an unidentified adulterant or an interfering substance, has abnormal physical characteristics, or has an endogenous substance at an abnormal concentration that prevents the laboratory from completing or obtaining a valid drug test result.”

    What do pain management doctors look for in urine test? ›

    The drug/class detected include marijuana, cocaine, opiates, phencyclidine (PCP), and amphethamines/methamphetamines. Additionally, it detects other substances such as benzodiazepines and barbiturates.

    What are some examples of co-occurring disorders? ›

    Co-occurring disorders can include anxiety disorders, depression, attention-deficit hyperactivity disorder (ADHD), bipolar disorder, personality disorders, and schizophrenia, among others.

    What are the three most common co-occurring disorders? ›

    5 Most Common Co-Occurring Disorders
    • 1 – Generalized Anxiety Disorder (GAD) ...
    • 2 – Attention Deficit Hyperactivity Disorder. ...
    • 3 – Post Traumatic Stress Disorder. ...
    • 4 – Clinical Depression. ...
    • 5 – Bipolar Disorder.
    Mar 7, 2022

    What are the 4 major clusters of PTSD? ›

    DSM-5 pays more attention to the behavioral symptoms that accompany PTSD and proposes four distinct diagnostic clusters instead of three. They are described as re-experiencing, avoidance, negative cognitions and mood, and arousal.

    Can hypersexuality be caused by trauma? ›

    Causes. The causes of hypersexual behavior are not well understood. Some children or adolescents may engage in increased or developmentally inappropriate sexual behavior as a result of traumatic experiences, stressors, or mental illness.

    What part of our brain triggers addiction? ›

    The part of the brain that causes addiction is called the mesolimbic dopamine pathway. It is sometimes called the reward circuit of the brain. Let's take a deeper look into the causes of addiction and how this area of the brain is impacted.

    Why do people become hypersexual from trauma? ›

    Many people feel hypersexual impulses as their brains are focused on the trauma. They can enter an unhealthy cycle where they seemingly reenact their trauma. As mentioned, this can be a coping mechanism for many.

    What type of mental illness is PTSD most similar to? ›

    Acute stress disorder (ASD).

    The symptoms of ASD are similar to PTSD, but occur within the first month after exposure to trauma. Prompt treatment and appropriate social support can reduce the risk of ASD developing into PTSD.

    What is the most common occurring diagnosis in people with PTSD? ›

    It is estimated that up to 80% of PTSD patients have a comorbid disorder, with the most common comorbidities being depression, anxiety, alcohol addiction, and substance abuse. There are 23 distinct marketed products for the treatment of PTSD, as seen below.

    What are the 3 clusters of symptoms of PTSD? ›

    Discussing the Effect of Trauma > The Three Symptom Clusters of...
    • Re-experiencing.
    • Avoidance and numbing.
    • Hyperarousal.

    What are the 5 forms of substance abuse? ›

    Believe they should lie to others to hide the effects of their parents problems.
    • Prescription Drug Abuse.
    • Illegal Drug Abuse.
    • Alcohol Abuse.
    • Solvent Abuse.
    • “Legal High” Abuse.
    Aug 3, 2016

    What is the diagnostic criteria for substance use disorder? ›

    These criteria fall under four basic categories — impaired control, physical dependence, social problems and risky use: Using more of a substance than intended or using it for longer than you're meant to.

    What is the most common type of substance use disorder? ›

    Alcohol use disorder is still the most common form of substance use disorder in America, fueled by widespread legal access and social approval of moderate drinking.

    What are the symptoms of substance use disorder? ›

    Warning Signs of Substance and Alcohol Use Disorder
    • Bloodshot eyes, pupils larger or smaller than usual.
    • Changes in appetite or sleep patterns.
    • Deterioration of physical appearance, personal grooming habits.
    • Runny nose or sniffling.
    • Sudden weight loss or weight gain.
    • Tremors, slurred speech, or impaired coordination.

    What are the 6 types of substance abuse? ›

    There are 6 types of drug dependence based on the type of substance being abused. These are alcohol, cannabis, hallucinogens, cocaine, opioids, and sedatives.

    What are the 6 causes of substance abuse? ›

    Here are some of the most common causes of drug or alcohol addiction in men and associated signals to watch for.
    • Expectations of Masculinity and Self-Medication. ...
    • Pressure Relating to Life Circumstances. ...
    • Genetic Predisposition to Substance Use. ...
    • Health Conditions. ...
    • Trauma or Adverse Childhood Experiences. ...
    • Grief.
    Feb 6, 2019

    What are the two social factors that contribute to substance abuse? ›

    Social Risk Factors Of Substance Abuse

    Social Factors that increase risk for adolescent substance use can include popularity, bullying, peer relationships, and association with gangs. Other possible factors are social and familial influences are often present simultaneously.

    What are the two types of substance abuse? ›

    There are two main types of substance use disorders: alcohol use disorder and drug use disorder. Some people abuse both substances, while others are addicted to one or the other.

    What social factors lead to substance abuse? ›

    Contributing factors of substance abuse

    Other risk factors include mental health illness such as anxiety or depression, isolation, lack of parental involvement, dysfunctional social relationships and poverty.

    Can PTSD cause addiction? ›

    With enough time and use, the PTSD sufferer can become addicted. Both disorders have a complex impact on the brain. It's crucial to treat PTSD and drug addiction simultaneously to undo this damage. Cognitive behavioral therapy (CBT) can help those with PTSD cope with their painful memories.

    Is trauma the root cause of addiction? ›

    The root causes of addiction include trauma, mental health struggles, and genetic predisposition. However, it's important to keep in mind that there is no one cause of addiction. No one can completely predict who will become addicted after substance abuse and who will not.

    Is trauma the main cause of addiction? ›

    One of the leading causes of developing addiction later in adult life is childhood trauma. A study of individuals being treated for substance use disorder and PTSD found that 77% of the sample had experienced at least one trauma as a child.

    Who is at highest risk for substance use disorder? ›

    People who have experienced physical, emotional or sexual abuse or trauma are more likely to develop a substance use disorder. Others who have friends who use, or those subjected to peer pressure, may also be at a greater risk.

    What are three risk factors for addiction? ›

    Other factors that put a person at risk for an addiction include parental substance misuse, trauma, and a lack of social attachments. These are called individual factors and they're part of the “big three” in areas of risk -- individual, environmental and genetic.

    What is an example of a risk factor for substance abuse? ›

    Early aggressive behavior, lack of parental supervision, academic problems, undiagnosed mental health problems, peer substance use, drug availability, poverty, peer rejection, and child abuse or neglect are risk factors associated with increased likelihood of youth substance use and abuse.

    What is the most common false positive drug test? ›

    Antidepressants, decongestants, and dextromethorphan (an ingredient in Robitussin, Delsym) are examples of medications that can cause false positive results. If you think you've had a false positive result on a urine drug test, talk to your healthcare provider.

    What can show up as benzodiazepine in a urine test? ›

    Benzodiazepines (Urine)
    • Alprazolam.
    • Chlordiazepoxide.
    • Clonazepam.
    • Clorazepate.
    • Diazepam.
    • Lorazepam.
    • Oxazepam.

    How do I dispute a false positive urine test? ›

    Consult a specialist who can represent and support you through the process.
    1. Step one: be transparent. If you use prescription medications or regularly eat foods like poppy seeds, notify the person testing you so they can take this into account. ...
    2. Step two: consult a professional. ...
    3. Step three: opt for a re-test.
    Mar 23, 2022

    What cant be detected in a urine test? ›

    A urinalysis is a test of your urine. It's used to detect and manage a wide range of disorders, such as urinary tract infections, kidney disease and diabetes. A urinalysis involves checking the appearance, concentration and content of urine.

    Can urine test give false result? ›

    Another common reason for getting a false negative is not having enough hCG in the urine you test. In early pregnancy, you can dilute the hormone concentration in your urine if you drink a lot of water before testing. This is more likely to happen in very early pregnancy when you take the test later in the day.

    How to do an observed urine drug screen? ›

    The observer must watch the urine go from the employee's body into the collection container. The observer must watch as the employee takes the specimen to the collector. The collector then completes the collection process.

    What do insurance companies look for in urine test? ›

    Your blood and urine samples will be tested for prescription drug use, tobacco use and whether you have any diseases. In addition, you may be weighed and asked questions about your lifestyle.

    How far back does a lab urine test go? ›

    What is the detection window for a lab-based, urine drug test? A: Urine drug testing typically detects recent drug use in the previous 24 to 72 hours.

    Why does trauma lead to substance abuse? ›

    Early traumatic experience may increase risk of substance use disorders (SUDs) because of attempts to self-medicate or to dampen mood symptoms associated with a dysregulated biological stress response.

    Why are trauma and addiction related? ›

    Emotional Trauma and Addiction

    Things such as bullying or emotional abuse can lead to mental health issues later in life, such as depression or anxiety. People who suffer from emotional trauma are more likely to struggle with addiction because they might use substances to numb the pain, deal with PTSD, or escape.

    What is the correlational relationship between substance use and violence? ›

    The correlation between substance abuse and violent behavior has been well documented. One study found that more than 26% of respondents who reported using alcohol, cannabis, and cocaine in a 12-month period, also reported committing a violent crime within the same time frame.

    What are the five factors of substance abuse? ›

    Risk factors
    • Family history of addiction. Drug addiction is more common in some families and likely involves an increased risk based on genes. ...
    • Mental health disorder. ...
    • Peer pressure. ...
    • Lack of family involvement. ...
    • Early use. ...
    • Taking a highly addictive drug.
    Oct 4, 2022

    What are the three most common triggers for relapse for substance abuse? ›

    Normal Feelings That Trigger Relapse
    • Nervousness.
    • Insecurity.
    • Boredom.
    • Sadness.
    • Embarrassment.
    • Loneliness.
    • Pressure.
    • Tiredness.

    What are the psychological causes of substance abuse? ›

    A person's genes, the action of the drug, peer pressure, emotional distress, anxiety, depression, and environmental stress can all be factors. Many who develop a substance use problem have depression, attention deficit disorder, post-traumatic stress disorder, or another mental problem.

    What are the symptoms of extreme PTSD? ›

    Common symptoms of PTSD
    • vivid flashbacks (feeling like the trauma is happening right now)
    • intrusive thoughts or images.
    • nightmares.
    • intense distress at real or symbolic reminders of the trauma.
    • physical sensations such as pain, sweating, nausea or trembling.

    What does PTSD do to your brain? ›

    PTSD causes your brain to get stuck in danger mode. Even after you're no longer in danger, it stays on high alert. Your body continues to send out stress signals, which lead to PTSD symptoms. Studies show that the part of the brain that handles fear and emotion (the amygdala) is more active in people with PTSD.

    What are symptoms of PTSD triggers? ›

    Changes in physical and emotional reactions
    • Being easily startled or frightened.
    • Always being on guard for danger.
    • Self-destructive behavior, such as drinking too much or driving too fast.
    • Trouble sleeping.
    • Trouble concentrating.
    • Irritability, angry outbursts or aggressive behavior.
    • Overwhelming guilt or shame.

    Does trauma justify abuse? ›

    Trauma may help explain why someone is primed to think, feel, behave, or react in certain manners or in certain contexts. But having experienced trauma is by no means a justification for harmful behavior—and no amount of trauma exempts a traumatized person from being held accountable if and when they hurt others.

    What are the 3 key elements of trauma? ›

    So, as discussed in the definition, there are three parts to trauma: event, experience of the event, and effect.

    What are three key characteristics of post traumatic growth? ›

    a strong support system. personality traits like extraversion and openness. the ability to integrate the traumatic experience. developing new belief systems after the traumatic experience.

    What are the 3 environmental factors that influence substance use and abuse? ›

    A breakdown of these factors is as follows:
    • Family and Home Life. Early childhood experiences can substantially influence addictive behavior. ...
    • Friend Groups. It can be challenging to avoid using substances when a person's social interactions rely heavily on these activities. ...
    • Trauma and Life Stressors. ...
    • Culture and Media.

    Videos

    1. The Vulnerable Brain: Pathways to and from Addiction with Yasmin Hurd, Ph.D.
    (Dana Foundation)
    2. The Struggle is Real: Substance Use/Abuse & Mental Health
    (BlackDoctor.org)
    3. High expectations: Impact of Cannabis on PTSD Recovery
    (UW PBSCI)
    4. Does Addiction Treatment Work? March 2019
    (Dawn Farm)
    5. Psychedelic Medicine: From Tradition to Science
    (Harvard Medical School)
    6. Basic Mechanisms and Processes that Facilitate or Impede Self-Management
    (Office of Behavioral and Social Sciences Research)
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